[용어정리] IC50, EC50, potency

IC50 : half maximal inhibitory concentration (IC50)의 약자로, 최대 억제 농도의 절반을 말함. 특정 생물학적 또는 생화학적 기능을 억제하는 물질의 효능을 측정한 값.

 

EC50 : Half maximal effective concentration (EC50)의 약자로, 최대 유효 농도의 절반은 지정된 노출 시간 후 기준선과 최대 값 사이의 중간에 반응을 유도하는 약물, 항체 또는 독성 물질의 농도를 나타냄. potency 보다 더 선호되어 쓰이는편.

 

potency : 약리학 분야에서 효능을 말함. 주어진 강도의 효과를 생성하는데 필요한 양으로 표현되는 약물 활성의 척도.

 

 

참고 : pubchemdocs.ncbi.nlm.nih.gov/glossary

• IC50: the concentration of a compound where 50% of its inhibitory activity is observed (See https://en.wikipedia.org/wiki/IC50)
• EC50: the concentration of a compound where 50% of its maximal effect is observed (See https://en.wikipedia.org/wiki/EC50)
• Kd: the equilibrium dissociation constant for the ligand, determined directly in a binding assay using a labelled ligand (See http://www.guidetopharmacology.org/helpPage.jsp and https://en.wikipedia.org/wiki/Dissociation_constant)
• Ki: the equilibrium dissociation constant for the ligand, determined in inhibition studies (See http://www.guidetopharmacology.org/helpPage.jsp and https://en.wikipedia.org/wiki/Competitive_inhibition)
• AC50/Potency: the concentration of a compound where 50% of the activity is observed. AC50 and Potency are often used in an exchangeable way among PubChem BioAssay submissions, and may represent IC50, EC50, CC50 etc. Please refer to a specific BioAssay record for details.